Arterial Remodeling of the Intracranial Arteries in Patients With Hypertension and Controls

The intracranial arteries play a major role in cerebrovascular disease, but arterial remodeling due to hypertension has not been well described humans. We aimed quantify this for: the basilar artery, vertebral, internal carotid, middle/anterior (inferior)/posterior cerebral, posterior communicating, and superior cerebellar of circle Willis. Ex vivo Willis specimens, selected from individuals with (n=24) without (n=25) history hypertension, were imaged at 7T magnetic resonance imaging using 3-dimensional gradient-echo sequence. Subsequently, histological analysis was performed. validated vessel wall thickness area measurements against histology. Next, we investigated potential differences between both groups techniques. Finally, analysis, stiffness atherosclerotic plaque severity load. All analyses unadjusted. Magnetic histology showed comparable (mean difference: 0.04 mm (limits agreement:−0.12 0.19 mm) (0.43 2 [−0.97 1.8 ]) measurements. observed no statistically significant either technique. Histological early advanced plaques almost all for groups. significantly higher carotid artery hypertensive group. Concluding, did observe thickening Using difference composition artery.